Evaluation of a distance learning course is a very critical phase of course improvement and is an indicator of the strengths and weaknesses of the course. In classical mode of Open and Distance Learning (ODL) system, the most important components of evaluation are the print materials and the student support which contribute to the success or failure of a course. The results of a feedback study on the evaluation of Biochemistry course, an elective course in the B.Sc. Programme offered by the School of Sciences, Indira Gandhi National Open University (IGNOU), are presented. The analysis of the feedback (from the experts in the field, peers, counsellors transacting the course at study centres and the learners in terms of the counselling, assignment and the content of the course) calls for revision of the course and inclusion of a laboratory component.